10 Insulin Side Effects Anyone Taking It Should Know | Diabetes Strong

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For people with type 1 diabetes and for some with type 2, daily insulin injections are absolutely critical. But insulin is a very complicated hormone, and taking it on a daily basis requires tremendous attention and management every day. In this article, we’ll discuss the potential side effects of insulin that anyone taking it should know. #diabetes #diabetestips #managingdiabetes #diabetesstrong #insulin #bloodsugar

For people with type 1 diabetes and for some with type 2, daily insulin injections are absolutely critical. 

But insulin is a very complicated hormone, and taking it on a daily basis requires tremendous attention and management every day.

In this article, we’ll discuss the potential side effects of insulin that anyone taking it should know.

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Table of Contents

What is insulin and why do you need it?

First of all, let’s make sure we all understand what insulin is and why it is a crucial part of what keeps you healthy and alive. Without any, you will die. Without enough, you will get very sick and eventually die.

Insulin is a peptide hormone produced by the beta cells of the pancreas. It’s secreted when the “GLUT2 transporter” detects a change in the “serum glucose level.” 

In other words, as your blood sugar starts to rise, your pancreas secretes more insulin to ensure that your blood sugar doesn’t get too high. The insulin takes the glucose in your bloodstream and carries to cells throughout your entire body that uses it for energy.

Your pancreas also secretes a steady drip of insulin 24 hours a day to meet your “background” insulin needs. Your body needs insulin every hour of every day in order to maintain normal blood sugar levels and function properly.

Even your brain relies on a second-by-second delivery of glucose in order to function — without insulin, your brain cannot make use of the glucose sitting in your bloodstream.

Even if you eat zero sugar or zero grams of carbohydrates, your body still needs insulin to survive.

In people with type 1 diabetes

In a person with type 1 diabetes, your immune system begins attacking and destroying most or all of your beta cells. Every day, your body is trying to produce insulin via the beta cells from your pancreas. And every day, your immune system continues to destroy them.

When a person develops type 1 diabetes, they generally become very sick very quickly — over the course of a few weeks or months — as blood sugar levels rise to life-threatening levels. 

People with type 1 diabetes must take insulin every single day either via an insulin pump or pod or via multiple daily injections with a syringe or insulin pen. Skipping an injection or a whole day of insulin could potentially be fatal.

In people with type 1 diabetes

In a person with type 1 diabetes, your immune system begins attacking and destroying most or all of your beta cells. Every day, your body is trying to produce insulin via the beta cells from your pancreas. And every day, your immune system continues to destroy them.

When a person develops type 1 diabetes, they generally become very sick very quickly — over the course of a few weeks or months — as blood sugar levels rise to life-threatening levels. 

People with type 1 diabetes must take insulin every single day either via an insulin pump or pod or via multiple daily injections with a syringe or insulin pen. Skipping an injection or a whole day of insulin could potentially be fatal.

In people with type 2 diabetes

In a person with type 2 diabetes, the body is either struggling to produce healthy beta cells, or the body is struggling with severe insulin resistance, making it difficult to maintain normal blood sugar levels.

The development of type 2 diabetes usually occurs over the course of months and years, first presenting as prediabetes until blood sugar levels are high enough to qualify as type 2 diabetes.

Some people with type 2 diabetes can improve (or “reverse”) their blood sugars through changes in their nutrition, exercise, and weight. 

However, many patients with type 2 diabetes are struggling to produce healthy beta cells which means they will need some type of medication to bring blood sugars down to a healthy level. For many, that best option may be insulin injections via a syringe or pen.

In people with type 1 diabetes

In a person with type 1 diabetes, your immune system begins attacking and destroying most or all of your beta cells. Every day, your body is trying to produce insulin via the beta cells from your pancreas. And every day, your immune system continues to destroy them.

When a person develops type 1 diabetes, they generally become very sick very quickly — over the course of a few weeks or months — as blood sugar levels rise to life-threatening levels. 

People with type 1 diabetes must take insulin every single day either via an insulin pump or pod or via multiple daily injections with a syringe or insulin pen. Skipping an injection or a whole day of insulin could potentially be fatal.

In people with type 2 diabetes

In a person with type 2 diabetes, the body is either struggling to produce healthy beta cells, or the body is struggling with severe insulin resistance, making it difficult to maintain normal blood sugar levels.

The development of type 2 diabetes usually occurs over the course of months and years, first presenting as prediabetes until blood sugar levels are high enough to qualify as type 2 diabetes.

Some people with type 2 diabetes can improve (or “reverse”) their blood sugars through changes in their nutrition, exercise, and weight. 

However, many patients with type 2 diabetes are struggling to produce healthy beta cells which means they will need some type of medication to bring blood sugars down to a healthy level. For many, that best option may be insulin injections via a syringe or pen.

Common side effects of insulin

Keep in mind that most of the side effects of insulin are actually the result of inaccurate doses and improper injection practices. When taken with great care and careful management, insulin is a critical part of what keeps you alive and healthy.

Low blood sugar

While the human body needs insulin to stay alive, too much can lead to low blood sugars (also known as “hypoglycemia”). Even one unit too much can lead to uncomfortable and dangerous symptoms

Symptoms of low blood sugar include:

  • Feeling shaky
  • Being nervous or anxious
  • Sweating, chills, and clamminess
  • Irritability or impatience
  • Confusion
  • Fast heartbeat
  • Feeling lightheaded or dizzy
  • Hunger
  • Nausea
  • Color draining from the skin (pallor)
  • Feeling Sleepy
  • Feeling weak or having no energy
  • Blurred/impaired vision
  • Tingling or numbness in the lips, tongue, or cheeks
  • Headaches
  • Coordination problems, clumsiness
  • Nightmares or crying out during sleep
  • Seizures

Read more on how to treat low blood sugars.

In people with type 1 diabetes

In a person with type 1 diabetes, your immune system begins attacking and destroying most or all of your beta cells. Every day, your body is trying to produce insulin via the beta cells from your pancreas. And every day, your immune system continues to destroy them.

When a person develops type 1 diabetes, they generally become very sick very quickly — over the course of a few weeks or months — as blood sugar levels rise to life-threatening levels. 

People with type 1 diabetes must take insulin every single day either via an insulin pump or pod or via multiple daily injections with a syringe or insulin pen. Skipping an injection or a whole day of insulin could potentially be fatal.

In people with type 2 diabetes

In a person with type 2 diabetes, the body is either struggling to produce healthy beta cells, or the body is struggling with severe insulin resistance, making it difficult to maintain normal blood sugar levels.

The development of type 2 diabetes usually occurs over the course of months and years, first presenting as prediabetes until blood sugar levels are high enough to qualify as type 2 diabetes.

Some people with type 2 diabetes can improve (or “reverse”) their blood sugars through changes in their nutrition, exercise, and weight. 

However, many patients with type 2 diabetes are struggling to produce healthy beta cells which means they will need some type of medication to bring blood sugars down to a healthy level. For many, that best option may be insulin injections via a syringe or pen.

Common side effects of insulin

Keep in mind that most of the side effects of insulin are actually the result of inaccurate doses and improper injection practices. When taken with great care and careful management, insulin is a critical part of what keeps you alive and healthy.

Low blood sugar

While the human body needs insulin to stay alive, too much can lead to low blood sugars (also known as “hypoglycemia”). Even one unit too much can lead to uncomfortable and dangerous symptoms

Symptoms of low blood sugar include:

  • Feeling shaky
  • Being nervous or anxious
  • Sweating, chills, and clamminess
  • Irritability or impatience
  • Confusion
  • Fast heartbeat
  • Feeling lightheaded or dizzy
  • Hunger
  • Nausea
  • Color draining from the skin (pallor)
  • Feeling Sleepy
  • Feeling weak or having no energy
  • Blurred/impaired vision
  • Tingling or numbness in the lips, tongue, or cheeks
  • Headaches
  • Coordination problems, clumsiness
  • Nightmares or crying out during sleep
  • Seizures

Read more on how to treat low blood sugars.

Lipohypertrophy

Lipohypertrophy is a common side effect of long-term insulin injections or insulin pump infusion sites. 

Lipohypertrophy is essentially a swollen lump of fatty tissue at the site of frequent injections. Insulin can actually cause the size of fat cells near frequent injection sites to increase.

Scar-tissue also usually develops at these locations because both are the result of frequent insulin injections.

In earlier years, when only human insulin was available, lipoatrophy was a similar issue of taking insulin but has since disappeared because human insulin is no longer used by most people.

Using a device to “roll” the tissue most commonly used for injections can help to prevent and breakdown lipohypertrophy lumps, but for those taking insulin every day, these lumps are inevitable to some degree.

The best thing you can do to minimize the development of lipohypertrophy is to consistently rotate where you inject insulin. Using the same location of your body over and over is going to create lumps from lipohypertrophy and scar-tissue.

Identifying areas affected by lipophypertrophy is also important because insulin will not be absorbed well at those sites. These lumps should tell you to start using different areas for your injections or infusion sites and improve your “injection site rotation” habits to prevent future issues.

In people with type 1 diabetes

In a person with type 1 diabetes, your immune system begins attacking and destroying most or all of your beta cells. Every day, your body is trying to produce insulin via the beta cells from your pancreas. And every day, your immune system continues to destroy them.

When a person develops type 1 diabetes, they generally become very sick very quickly — over the course of a few weeks or months — as blood sugar levels rise to life-threatening levels. 

People with type 1 diabetes must take insulin every single day either via an insulin pump or pod or via multiple daily injections with a syringe or insulin pen. Skipping an injection or a whole day of insulin could potentially be fatal.

In people with type 2 diabetes

In a person with type 2 diabetes, the body is either struggling to produce healthy beta cells, or the body is struggling with severe insulin resistance, making it difficult to maintain normal blood sugar levels.

The development of type 2 diabetes usually occurs over the course of months and years, first presenting as prediabetes until blood sugar levels are high enough to qualify as type 2 diabetes.

Some people with type 2 diabetes can improve (or “reverse”) their blood sugars through changes in their nutrition, exercise, and weight. 

However, many patients with type 2 diabetes are struggling to produce healthy beta cells which means they will need some type of medication to bring blood sugars down to a healthy level. For many, that best option may be insulin injections via a syringe or pen.

Common side effects of insulin

Keep in mind that most of the side effects of insulin are actually the result of inaccurate doses and improper injection practices. When taken with great care and careful management, insulin is a critical part of what keeps you alive and healthy.

Low blood sugar

While the human body needs insulin to stay alive, too much can lead to low blood sugars (also known as “hypoglycemia”). Even one unit too much can lead to uncomfortable and dangerous symptoms

Symptoms of low blood sugar include:

  • Feeling shaky
  • Being nervous or anxious
  • Sweating, chills, and clamminess
  • Irritability or impatience
  • Confusion
  • Fast heartbeat
  • Feeling lightheaded or dizzy
  • Hunger
  • Nausea
  • Color draining from the skin (pallor)
  • Feeling Sleepy
  • Feeling weak or having no energy
  • Blurred/impaired vision
  • Tingling or numbness in the lips, tongue, or cheeks
  • Headaches
  • Coordination problems, clumsiness
  • Nightmares or crying out during sleep
  • Seizures

Read more on how to treat low blood sugars.

Lipohypertrophy

Lipohypertrophy is a common side effect of long-term insulin injections or insulin pump infusion sites. 

Lipohypertrophy is essentially a swollen lump of fatty tissue at the site of frequent injections. Insulin can actually cause the size of fat cells near frequent injection sites to increase.

Scar-tissue also usually develops at these locations because both are the result of frequent insulin injections.

In earlier years, when only human insulin was available, lipoatrophy was a similar issue of taking insulin but has since disappeared because human insulin is no longer used by most people.

Using a device to “roll” the tissue most commonly used for injections can help to prevent and breakdown lipohypertrophy lumps, but for those taking insulin every day, these lumps are inevitable to some degree.

The best thing you can do to minimize the development of lipohypertrophy is to consistently rotate where you inject insulin. Using the same location of your body over and over is going to create lumps from lipohypertrophy and scar-tissue.

Identifying areas affected by lipophypertrophy is also important because insulin will not be absorbed well at those sites. These lumps should tell you to start using different areas for your injections or infusion sites and improve your “injection site rotation” habits to prevent future issues.

Burning

Some insulin can burn during or immediately after injection. This is common in long-acting insulins like Lantus and Basalgar because they have a high acidity level. 

Other insulin could sting or burn if you injected into muscle tissue rather than body fat, or if you simply hit a sensitive area or an area used too frequently for injections that needs to heal.

Preventing the burning sensation from acidic insulins, however, is tricky. Some recommend placing an ice-pack on the area before injecting. It can help but it likely won’t eliminate the burning sensation entirely.

In people with type 1 diabetes

In a person with type 1 diabetes, your immune system begins attacking and destroying most or all of your beta cells. Every day, your body is trying to produce insulin via the beta cells from your pancreas. And every day, your immune system continues to destroy them.

When a person develops type 1 diabetes, they generally become very sick very quickly — over the course of a few weeks or months — as blood sugar levels rise to life-threatening levels. 

People with type 1 diabetes must take insulin every single day either via an insulin pump or pod or via multiple daily injections with a syringe or insulin pen. Skipping an injection or a whole day of insulin could potentially be fatal.

In people with type 2 diabetes

In a person with type 2 diabetes, the body is either struggling to produce healthy beta cells, or the body is struggling with severe insulin resistance, making it difficult to maintain normal blood sugar levels.

The development of type 2 diabetes usually occurs over the course of months and years, first presenting as prediabetes until blood sugar levels are high enough to qualify as type 2 diabetes.

Some people with type 2 diabetes can improve (or “reverse”) their blood sugars through changes in their nutrition, exercise, and weight. 

However, many patients with type 2 diabetes are struggling to produce healthy beta cells which means they will need some type of medication to bring blood sugars down to a healthy level. For many, that best option may be insulin injections via a syringe or pen.

Common side effects of insulin

Keep in mind that most of the side effects of insulin are actually the result of inaccurate doses and improper injection practices. When taken with great care and careful management, insulin is a critical part of what keeps you alive and healthy.

Low blood sugar

While the human body needs insulin to stay alive, too much can lead to low blood sugars (also known as “hypoglycemia”). Even one unit too much can lead to uncomfortable and dangerous symptoms

Symptoms of low blood sugar include:

  • Feeling shaky
  • Being nervous or anxious
  • Sweating, chills, and clamminess
  • Irritability or impatience
  • Confusion
  • Fast heartbeat
  • Feeling lightheaded or dizzy
  • Hunger
  • Nausea
  • Color draining from the skin (pallor)
  • Feeling Sleepy
  • Feeling weak or having no energy
  • Blurred/impaired vision
  • Tingling or numbness in the lips, tongue, or cheeks
  • Headaches
  • Coordination problems, clumsiness
  • Nightmares or crying out during sleep
  • Seizures

Read more on how to treat low blood sugars.

Lipohypertrophy

Lipohypertrophy is a common side effect of long-term insulin injections or insulin pump infusion sites. 

Lipohypertrophy is essentially a swollen lump of fatty tissue at the site of frequent injections. Insulin can actually cause the size of fat cells near frequent injection sites to increase.

Scar-tissue also usually develops at these locations because both are the result of frequent insulin injections.

In earlier years, when only human insulin was available, lipoatrophy was a similar issue of taking insulin but has since disappeared because human insulin is no longer used by most people.

Using a device to “roll” the tissue most commonly used for injections can help to prevent and breakdown lipohypertrophy lumps, but for those taking insulin every day, these lumps are inevitable to some degree.

The best thing you can do to minimize the development of lipohypertrophy is to consistently rotate where you inject insulin. Using the same location of your body over and over is going to create lumps from lipohypertrophy and scar-tissue.

Identifying areas affected by lipophypertrophy is also important because insulin will not be absorbed well at those sites. These lumps should tell you to start using different areas for your injections or infusion sites and improve your “injection site rotation” habits to prevent future issues.

Burning

Some insulin can burn during or immediately after injection. This is common in long-acting insulins like Lantus and Basalgar because they have a high acidity level. 

Other insulin could sting or burn if you injected into muscle tissue rather than body fat, or if you simply hit a sensitive area or an area used too frequently for injections that needs to heal.

Preventing the burning sensation from acidic insulins, however, is tricky. Some recommend placing an ice-pack on the area before injecting. It can help but it likely won’t eliminate the burning sensation entirely.

Rash and allergic reaction

Less than 4 percent of people with diabetes have a hypersensitivity or allergy to insulin, but if you’re one of those 4 percent, it’s a significant challenge. 

It’s believed that a person’s allergic reaction is in response to additives and peptides within commercially manufactured insulin.

The symptoms of an insulin allergy include:

  • Swelling at the injection site
  • Intense rash, hives, and itching
  • Low blood pressure
  • Swelling within your throat and mouth
  • Difficulty breathing (anaphylaxis)

“Insulin allergies can be local or systemic, as well as immediate or delayed,” explains a 2016 study. “The underlying mechanisms of insulin-associated allergy can be divided into three types: type I (IgE-mediated), type III (IgG-mediated immune complex), and type IV (T-cell-mediated delayed-type) hypersensitivity. Type I hypersensitivity, which manifests as local edema, itching, wheals, and flares, is the most common form.” 

To date, there is no single treatment method that has proven effective enough to be widely used.

“Various treatment options, ranging from symptom relief using simple antihistaminics to more complicated insulin desensitization therapy, have been advocated for managing allergic reactions to insulin,” explains the study.

While steroids can also significantly help with the allergic reaction, they create tremendous insulin resistance and make blood sugar management very difficult, so it’s not a realistic long-term solution. 

Scar-tissue 

Rotating your injection sites is crucial in preventing the build-up of scar tissue. If you inject into the same area of your body over and over every day, your body will build-up a harder fibrous tissue every time it heals from the injury of that injection. 

Over time that build-up of scar tissue will interfere with your body’s ability to properly absorb the insulin you injected, leading to high blood sugar levels.

By making an effort to inject in different areas of the body (thigh, belly, back of the arm, buttocks, etc.) and different parts of each area (upper thigh vs. lower thigh, etc.) you can prevent the rapid build-up of scar tissue. 

For those who take multiple injections each day or those who use insulin pumps, some scar tissue is inevitable.

In people with type 1 diabetes

In a person with type 1 diabetes, your immune system begins attacking and destroying most or all of your beta cells. Every day, your body is trying to produce insulin via the beta cells from your pancreas. And every day, your immune system continues to destroy them.

When a person develops type 1 diabetes, they generally become very sick very quickly — over the course of a few weeks or months — as blood sugar levels rise to life-threatening levels. 

People with type 1 diabetes must take insulin every single day either via an insulin pump or pod or via multiple daily injections with a syringe or insulin pen. Skipping an injection or a whole day of insulin could potentially be fatal.

In people with type 2 diabetes

In a person with type 2 diabetes, the body is either struggling to produce healthy beta cells, or the body is struggling with severe insulin resistance, making it difficult to maintain normal blood sugar levels.

The development of type 2 diabetes usually occurs over the course of months and years, first presenting as prediabetes until blood sugar levels are high enough to qualify as type 2 diabetes.

Some people with type 2 diabetes can improve (or “reverse”) their blood sugars through changes in their nutrition, exercise, and weight. 

However, many patients with type 2 diabetes are struggling to produce healthy beta cells which means they will need some type of medication to bring blood sugars down to a healthy level. For many, that best option may be insulin injections via a syringe or pen.

Common side effects of insulin

Keep in mind that most of the side effects of insulin are actually the result of inaccurate doses and improper injection practices. When taken with great care and careful management, insulin is a critical part of what keeps you alive and healthy.

Low blood sugar

While the human body needs insulin to stay alive, too much can lead to low blood sugars (also known as “hypoglycemia”). Even one unit too much can lead to uncomfortable and dangerous symptoms

Symptoms of low blood sugar include:

  • Feeling shaky
  • Being nervous or anxious
  • Sweating, chills, and clamminess
  • Irritability or impatience
  • Confusion
  • Fast heartbeat
  • Feeling lightheaded or dizzy
  • Hunger
  • Nausea
  • Color draining from the skin (pallor)
  • Feeling Sleepy
  • Feeling weak or having no energy
  • Blurred/impaired vision
  • Tingling or numbness in the lips, tongue, or cheeks
  • Headaches
  • Coordination problems, clumsiness
  • Nightmares or crying out during sleep
  • Seizures

Read more on how to treat low blood sugars.

Lipohypertrophy

Lipohypertrophy is a common side effect of long-term insulin injections or insulin pump infusion sites. 

Lipohypertrophy is essentially a swollen lump of fatty tissue at the site of frequent injections. Insulin can actually cause the size of fat cells near frequent injection sites to increase.

Scar-tissue also usually develops at these locations because both are the result of frequent insulin injections.

In earlier years, when only human insulin was available, lipoatrophy was a similar issue of taking insulin but has since disappeared because human insulin is no longer used by most people.

Using a device to “roll” the tissue most commonly used for injections can help to prevent and breakdown lipohypertrophy lumps, but for those taking insulin every day, these lumps are inevitable to some degree.

The best thing you can do to minimize the development of lipohypertrophy is to consistently rotate where you inject insulin. Using the same location of your body over and over is going to create lumps from lipohypertrophy and scar-tissue.

Identifying areas affected by lipophypertrophy is also important because insulin will not be absorbed well at those sites. These lumps should tell you to start using different areas for your injections or infusion sites and improve your “injection site rotation” habits to prevent future issues.

Burning

Some insulin can burn during or immediately after injection. This is common in long-acting insulins like Lantus and Basalgar because they have a high acidity level. 

Other insulin could sting or burn if you injected into muscle tissue rather than body fat, or if you simply hit a sensitive area or an area used too frequently for injections that needs to heal.

Preventing the burning sensation from acidic insulins, however, is tricky. Some recommend placing an ice-pack on the area before injecting. It can help but it likely won’t eliminate the burning sensation entirely.

Rash and allergic reaction

Less than 4 percent of people with diabetes have a hypersensitivity or allergy to insulin, but if you’re one of those 4 percent, it’s a significant challenge. 

It’s believed that a person’s allergic reaction is in response to additives and peptides within commercially manufactured insulin.

The symptoms of an insulin allergy include:

  • Swelling at the injection site
  • Intense rash, hives, and itching
  • Low blood pressure
  • Swelling within your throat and mouth
  • Difficulty breathing (anaphylaxis)

“Insulin allergies can be local or systemic, as well as immediate or delayed,” explains a 2016 study. “The underlying mechanisms of insulin-associated allergy can be divided into three types: type I (IgE-mediated), type III (IgG-mediated immune complex), and type IV (T-cell-mediated delayed-type) hypersensitivity. Type I hypersensitivity, which manifests as local edema, itching, wheals, and flares, is the most common form.” 

To date, there is no single treatment method that has proven effective enough to be widely used.

“Various treatment options, ranging from symptom relief using simple antihistaminics to more complicated insulin desensitization therapy, have been advocated for managing allergic reactions to insulin,” explains the study.

While steroids can also significantly help with the allergic reaction, they create tremendous insulin resistance and make blood sugar management very difficult, so it’s not a realistic long-term solution. 

Scar-tissue 

Rotating your injection sites is crucial in preventing the build-up of scar tissue. If you inject into the same area of your body over and over every day, your body will build-up a harder fibrous tissue every time it heals from the injury of that injection. 

Over time that build-up of scar tissue will interfere with your body’s ability to properly absorb the insulin you injected, leading to high blood sugar levels.

By making an effort to inject in different areas of the body (thigh, belly, back of the arm, buttocks, etc.) and different parts of each area (upper thigh vs. lower thigh, etc.) you can prevent the rapid build-up of scar tissue. 

For those who take multiple injections each day or those who use insulin pumps, some scar tissue is inevitable.

Bruising & site irritation

Sometimes, you just hit the wrong spot with your syringe or pen needle, and it creates a small bruise. Insulin pumps and pods can create bruising as well. 

The solution is fairly simple: rotation, rotation, rotation. Rotating your injection sites can help prevent creating too much damage to one area. 

If you notice a bruise or an irritated injection site, try to avoid that particular site (and around it) for the next week or two so it can heal. 

If the irritation persists or the bruising spreads instead of minimizes, contact your healthcare team immediately or visit an Urgent Care clinic to be sure it hasn’t become infected.

https://diabetesstrong.com/insulin-side-effects/

2 thoughts on “10 Insulin Side Effects Anyone Taking It Should Know | Diabetes Strong”

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